Tuberostemonine

An alkaloid with diverse biological activities

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库存: 现货

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5mg

￥550.00

440.00

- +
10mg

￥912.00

730.00

- +
20mg

￥1625.00

1300.00

- +

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Background

Tuberostemonine is an alkaloid that has been found in S. tuberosa and has diverse biological activities.^1,2,3 It exhibits feeding deterrent and repellant activities against S. littoralis fifth instar larvae when applied to lettuce leaf disks at concentrations of 0.01 and 0.1 ?g/cm², respectively.¹ Tuberostemonine (100 mg/kg) reduces the number of citric acid-induced coughs in guinea pigs.² In vivo, tuberostemonine (1-10 mg/kg) decreases bronchoalveolar lavage fluid (BALF) neutrophil and macrophage, but not lymphocyte, infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in a cigarette smoke-induced mouse model of acute lung inflammation.³

1.Brem, B., Seger, C., Pacher, T., et al.Feeding deterrence and contact toxicity of Stemona alkaloids-a source of potent natural insecticidesJ. Agric. Food Chem.50(22)6383-6388(2002) 2.Zhou, X., Leung, P.H.H., Li, N., et al.Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosaPlanta Med.75(6)575-580(2009) 3.Jung, K.-H., Beak, H., Park, S., et al.The therapeutic effects of tuberostemonine against cigarette smoke-induced acute lung inflammation in miceEur. J. Pharmacol.77480-86(2016)