Vincristine

An antimitotic inhibitor of tubulin polymerization

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库存: 现货

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数量
1mg

￥375.00

300.00

- +
5mg

￥650.00

520.00

- +
10mg

￥1100.00

880.00

- +
20mg

￥1962.00

1570.00

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货号: ajcn4742
CAS: 57-22-7
别名: 长春新碱,Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
分子式: C46H56N4O10
分子量: 824.96
纯度: >98%
溶解度: Soluble in DMSO
储存: Store at -20°C, protect from light
库存: 现货

Background

Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (K_i = 85 nM) and inhibiting tubulin polymerization.^1,2 Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.³ Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.⁴

1.Jordan, M.A., Himes, R.H., and Wilson, L.Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitroCancer Res.45(6)2741-2747(1985) 2.Towle, M.J., Salvato, K.A., Wels, B.F., et al.Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditionsCancer Res.71(2)496-505(2011) 3.van Tellingen, O., Buckle, T., Jonker, J.W., et al.P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivoBr. J. Cancer89(9)1776-1782(2003) 4.Chan, H.S.L., Haddad, G., Thorner, P.S., et al.P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastomaNew Engl. J. Med.325(23)1608-1614(1991)