An alkaloid with diverse biological activities
Phellodendrine is an alkaloid that has been found in P. amurense and has diverse biological activities.1,2,3 It inhibits acetylcholinesterase (AChE) activity (IC50 = 36.51 ?M) and scavenges ABTS radicals in cell-free assays when used at concentrations ranging from 12.5 to 100 ?M.2 Phellodendrine induces apoptosis in PANC-1 pancreatic cancer cells and reduces tumor growth in a PANC-1 mouse xenograft model.1 It inhibits the local graft versus host (GVH) reaction in irradiated mice receiving splenocyte grafts, indicating immunosuppressant activity, when administered at a dose of 20 mg/kg.3
1.Thu, P.M., Zheng, Z.-G., Zhou, Y.-P., et al.Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosisEur. J. Pharmacol.85023-34(2019) 2.Kim, Y.J., Lim, H.-Y., Kim, Y., et al.Phytochemical quantification and the in vitro acetylcholinesterase inhibitory activity of Phellodendron chinense and its componentsMolecules22(6)925(2017) 3.Mori, H., Fuchigami, M., Inoue, N., et al.Principle of the bark of Phellodendron amurense to suppress the cellular immune response: effect of phellodendrine on cellular and humoral immune responsesPlanta Med.61(1)45-49(1995)
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