An ODC inhibitor
Herbacetin is a natural product that acts as a selective inhibitor of ornithine decarboxylase (ODC).1 It inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner while having no effect on 13 tested kinases or S-adenosylmethionine decarboxylase in vitro. Herbacetin suppresses anchorage-independent growth, activation of activator protein-1 (AP-1), a MAP kinase transcription factor, and phosphorylation of ERK1/2 and p90RSK in vitro. It suppresses HCT116 xenograft tumor growth in mice without significant body weight loss when administered i.p. or orally. Herbacetin also inhibits acetylcholinesterase (AChE; IC50 = 1.37 μM) in vitro.2
1.Kim, D.J., Roh, E.J., Lee, M.-H., et al.Herbacetin is a novel allosteric inhibitor of ornithine decarboxylase with antitumor activityCancer Res.76(5)1146-1157(2016) 2.Li, F.J., Liu, Y., Yuan, Y., et al.Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of Rhodiola crenulata using molecular docking and isothermal titration calorimetry methodsInt. J. Biol. Macromol.104(Pt. A)527-532(2017)
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