Prostaglandin D2 Ethanolamide

An endogenous anandamide metabolite

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库存: 现货

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500ug

￥937.00

750.00

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1mg

￥1487.00

1190.00

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5mg

￥6937.00

5550.00

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货号: ajcf11934
CAS: 398138-28-8
别名: PGD2EA, Prostamide D2
分子式: C22H37NO5
分子量: 395.5
纯度: >98%
溶解度: DMF: 8.3 mg/ml,DMSO: 8.3 mg/ml,Ethanol: 12.5 mg/ml,PBS (7.2): 2.5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase. PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor. It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.