113-O12B

An ionizable cationic lipidoid

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库存: 现货

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5mg

￥1837.00

1470.00

- +
10mg

￥3312.00

2650.00

- +
25mg

￥7312.00

5850.00

- +

已选 0 种 0 瓶

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Background

113-O12B is a disulfide bond-containing ionizable cationic lipidoid.¹ It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8⁺ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.

1.Chen, J., Ye, Z., Huang, C., et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell responseProc. Natl. Acad. Sci. USA119(34)e2207841119(2022)