HMG-CoA(Hydroxymethylglutaryl-CoA)
HMG-CoA(DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium)是 HMG 辅酶 A 的二钠盐化合物，是合成萜烯、酮体的关键中间体。DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium 在体内参与酯类代谢，是胆固醇合成的前体，可耦连 LDL 受体调节胆固醇合成。
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包装价格促销价数量
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1mg￥2500.002000.00- +
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5mg￥5000.004000.00- +
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25mg￥10625.007500.00- +
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100mg￥18000.000.00- +
- 货号: ajcf16986
- CAS: 103476-21-7
- 别名: 三羟基三甲基戊二酸单酰辅酶A(HMG-COA)
- 分子式: C27H44N7Na2O20P3S
- 分子量: 957.64
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C
- 库存: 现货
Background
HMG-CoA已用于在药物治疗中研究其对mTORC1调控的影响。它还用于比较两种反应性酰基辅酶A（如HMG-CoA和Glutaryl-CoA;戊二酰辅酶A）的酰化蛋白组。
HMG-CoA可作为胆固醇合成的前体，抑制羟甲基戊二酰辅酶A(HMG-CoA)会降低胆固醇的生成。它在血液中可转化生成β-羟基丁酸。羟甲基戊二酰辅酶A(HMG-CoA)是胆固醇生物合成的调节酶，可偶联LDL受体调节胆固醇合成，受到抑制后会降低胆固醇的生成。
HMG-CoA可作为底物用于研究3-羟基-3-甲戊二酰辅酶A(HMG-CoA)还原酶的特异性和动力学。 羟甲基戊二酰辅酶A(HMG-CoA)是萜类和酮类生物合成的关键中间体。它的代谢是他汀类药物的靶点，通过其控制胆固醇水平。
DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].
3-hydroxy-3-methylglutaryl CoA (HMG-CoA) comes from acetyl-coa and acetyl-CoA converted from HMG-CoA synthetase, mainly dependents on oxidative reactions in mitochondria[1].
[1]. Millán Nú?ez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish.
[2]. Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01):7-11.
