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Procyanidin B3
A polyphenol flavonoid dimer with diverse biological activities
Tubacin
Tubacin (tubulin acetylation inducer) is a small molecule that selectively inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin with IC50 of 0.004μM
BRD73954
A dual inhibitor of HDAC6 and HDAC8
SIS17
SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
HDAC6-IN-1
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability.
Droxinostat
An inhibitor of HDAC3, HDAC6, and HDAC8
Givinostat (ITF-2357)
HDAC inhibitor with anti-inflammatory and antineoplastic activities
ACY-738
An HDAC6 inhibitor
Pracinostat (SB939)
A pan-HDAC inhibitor
Chidamide
An HDAC inhibitor
Tubastatin A (trifluoroacetate salt)
A potent HDAC6 inhibitor
Panobinostat (LBH589)
Pomiferin (NSC 5113)
Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂,其 IC50 为 1.05 μM,并且还有效抑制 mTOR (IC50, 6.2 μM)。
TMP269
A selective class IIa HDAC inhibitor
CRA-026440
CRA-026440 是一种有效的广谱 HDAC 抑制剂。