Cell Cycle/DNA Damage

Aurora Kinase

HSP (Heat shock proteins)

HDAC (Histone deacetylases)

Deubiquitinase

Casein Kinase

Checkpoint Kinase (Chk)

NA-PKcs (DNA-dependent protein kinase, catalytic subunit)

DNA/RNA Synthesis

CDK

ATM/ATR

Antifolate

DNA Alkylator/Crosslinker

PI3K/Akt/mTOR

PTEN (Phosphatase and tensin homologue deleted on chromosome 10)

mTOR (mammalian target of Rapamycin)

MELK (Maternal embryonic leucine zipper kinase)

Glycogen synthase kinase 3 (GSK-3)

PI3K (Phosphoinositide 3-kinase)

Akt/PKB (Protein kinase B)

PDK-1 (phosphoinositide dependent protein kinase-1)

Epigenetics

Histone Methyltransferase

Janus kinase (JAK)

PARP

PKC (Protein kinase C)

AMPK

Sirtuin (Sir2 proteins)

DNA Methyltransferase

Epigenetic Reader Domain

Apoptosis(all)

MDM-2/p53

Apoptosis

RIP kinase

Bcl-2 Family

Ferroptosis

Caspase

TNF Receptor

PKD (Protein kinase D)

DAPK

FKBP (FK506-binding protein)

GPCR/G Protein

Angiotensin Receptor

Cannabinoid Receptor

5-HT Receptor

Adenosine Receptor

Adrenergic Receptor

CCR (Chemokine receptors)

CXCRs (CXC chemokine receptors)

Endothelin Receptor

MAPK/ERK Pathway

MEK

p38 MAPK

Raf

ERK

JNK/JNKs (c-Jun N-terminal kinases)

Ribosomal S6 Kinase (RSK)

MAP3K/MAP4K

Cytoskeleton

Microtubule/Tubulin

Monopolar spindle 1 (Mps1)

Integrin

PAKs (p21-activated kinases)

Gap Junction Protein

Kinesin

Arp2/3 Complex

Anti infection

Bacterial

HBV

HIV

HCV

Influenza virus

HSV

RSV (Respiratory syncytial virus)

Parasite

Membrane Transporter/Ion Channel

iGluR (ionotropic glutamate receptor)

GABA Receptor

Calcium Channel

CFTR (Cystic fibrosis transmembrane conductance regulator)

nAChR/nAChRs (nicotinic acetylcholine receptors)

Na+/K+-ATPase

ATP Synthase

Chloride Channel

BCRP(breast cancer resistant protein)

Protein Tyrosine Kinase/RTK

FGFR (Fibroblast growth factor receptors)

ALK (Anaplastic lymphoma kinase)

c-Met (hepatocyte growth factor receptor, HGFR)

Bcr-Abl

c-Kit

FAK (Focal Adhesion Kinase or PTK2)

Bruton tyrosine kinase (Btk)

FLT3 (Fms-like tyrosine kinase 3, CD135)

c-FMS (CSF1R, CSF-1R)

DYRK

IGF-1R (Insulin-like growth factor 1 receptor)

Discoidin Domain Receptor

JAK/STAT Signaling

EGFR

Pim kinases

STAT

NF-κB(all)

NF-κB

IKK (IκB kinase)

Keap1-Nrf2

Reactive oxygen species (ROS)

Immunology/Inflammation

Arginase

NO Synthase

Cyclooxygenase (COX)

Aryl Hydrocarbon Receptor

Interleukin-1 receptor-associated kinase (IRAK)

PD-1/PD-L1

Complement System

NOD-like Receptor (NLR)

Interleukin Related

Neuronal Signaling

Dopamine Receptor

GPR119

Beta-secretase (BACE)

Cholecystokinin Receptor

FAAH (Fatty acid amide hydrolase)

Ca2+/calmodulin-dependent kinase (CaMK)

Acetylcholinesterase (AChE or acetylhydrolase)

Dopamine Transporter

Amyloid-β

Catechol O-methyltransferase (COMT)

Stem Cell/Wnt

Wnt

Notch

Hedgehog (Hh)

ROCK

Autophagy(all)

Leucine-rich repeat kinase 2 (LRRK2)

Autophagy

ULK1/ULK2

TGF-beta/Smad

Transforming growth factor-beta (TGF-beta)

PROTAC

E3 Ligase Ligand-Linker Conjugate

SNIPER

Ligand for Target Protein for PROTAC

Antibody-drug Conjugate/ADC Related

Metabolic Enzyme/Protease

Aldose Reductase

Aldehyde Dehydrogenase (ALDH)

Angiotensin-converting Enzyme (ACE)

Cathepsin

Aminopeptidase

ATP Citrate Lyase

5 alpha Reductase

Acyltransferase

Aminoacyl-tRNA Synthetase

Acetyl-CoA carboxylase (ACC)

Carbonic Anhydrase

Others

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