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Ivacaftor benzenesulfonate
A CFTR potentiator
Ivacaftor hydrate
DNA31
DNA31 是囊性纤维化跨膜传导调节因子 (CFTR) 基因的全球最常见的 31 种突变。DNA31 用于针对囊性纤维化 (CF) 的新生儿筛查方案的第一级遗传测试。
GLPG2451
GLPG2451 是一种囊性纤维化跨膜电导调节器 (CFTR) 的增强剂,有效增强低温挽救的 F508del CFTR,EC50 为 11.1 nM。
PTC124(Ataluren)
Selective inducer of stop codon read-through
Ivacaftor (VX-770)
IOWH-032
A modulator of CFTR
CFTRinh-172
A potent CFTR channel blocker
VX-661
An investigational compound that promotes the maturation of delta F508 CFTR
VX-809
A F508del-CFTR corrector
BPO-27 racemate
BPO-27racemate是有效的CFTR抑制剂,IC50值为8nM。
GLPG1837(ABBV-974)
GlyH-101
A reversible CFTR channel blocker
CFTR corrector 2
FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein.
PPQ-102
A CFTR channel inhibitor