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Saredutant (SR 48968)

Saredutant (SR 48968) 是一种选择性 NK2 受体拮抗剂。

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Saredutant (SR 48968)的二维码
  • 库存: 现货
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  • 1mg
    ¥1962.00
    1570.00
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  • 5mg
    ¥3775.00
    3020.00
    - +
  • 10mg
    ¥5937.00
    4750.00
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  • 25mg
    ¥10687.00
    8550.00
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  • 50mg
    ¥17625.00
    14100.00
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  • 100mg
    ¥24037.00
    19230.00
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  • 货号: ajcx12510
  • CAS: 142001-63-6
  • 别名: SR 48968; SR 48968C
  • 分子式: C31H35Cl2N3O2
  • 分子量: 552.53
  • 纯度: >98%
  • 溶解度: DMSO: 250 mg/mL (452.46 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Saredutant is a selective NK2 receptor antagonist.


Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility[1].


[1]. Overstreet DH, et al. Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with Desipramine in an animal model of depression. Pharmacol Biochem Behav. 2010 Aug;96(2):206-10.

Protocol

Animal experiment:

Rats[1]In the first experiment the dose-related effects of Saredutant are investigated. The Flinders Sensitive Line (FSL) rats (n=8) are treated with one of the following: vehicle (carboxymethylcellulose-CMC) or 1, 3, or 10 mg/kg Saredutant, or 5 mg/kg Desipramine as a positive control. Saredutant is injected at 1 mL/kg. The Flinders Resistant Line (FRL) rats are given CMC or 3 mg/kg Saredutant. All injections are i.p. and are given for 14 consecutive days. Approximately 22 h after the last injections the rats are placed in the social interaction chamber with similarly treated rats for a 5-min recording. Then about 2 h later the rats are individually tested in the forced swim test for a single 5-min session[1].

参考文献:

[1]. Overstreet DH, et al. Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with Desipramine in an animal model of depression. Pharmacol Biochem Behav. 2010 Aug;96(2):206-10.

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