Chloramphenicol succinate sodium

A prodrug form of chloramphenicol

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500mg

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440.00

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货号: ajcx17056
CAS: 982-57-0
别名: 氯霉素琥珀酸钠
分子式: C15H15Cl2N2NaO8
分子量: 445.18
纯度: >98%
溶解度: DMSO: 250 mg/mL (561.57 mM)
储存: -20°C, protect from light, stored under argon
库存: 现货

Background

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.¹ It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro.² Chloramphenicol succinate reduces human leukocyte migration in vitro.³ In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively.⁴ Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury.⁵ Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.

1.Ceriotti, G., Defranceschi, A., De Carneri, I., et al.Chloramphenicol succinate, a water-soluble derivative of chloramphenicolFarmaco Sci.9(1)21-38(1954) 2.Ambekar, C.S., Lee, J.S., Cheung, B.M., et al.Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: Possible reason for its toxicityToxicol. In Vitro18(4)441-447(2004) 3.Forsgren, A., and Schmeling, D.Effect of antibiotics of chemotaxis of human leukocytesAntimicrob. Agents Chemother.11(4)590-584(1977) 4.Prat, V., Konickova, L., Ritzerfeld, W., et al.Effect of chloramphenicol against different E. coli strains in vitro and in experimental pyelonephritisArzneimittelforschung18(9)1123-1127(1968) 5.Sala-Mercado, J.A., Wider, J., Undyala, V.V., et al.Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injuryCirculation122(11 Suppl)S179-S184(2010)