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An esterified version of (±)14(15)-EET
(±)14(15)-EET is biosynthesized in rat and rabbit liver microsomes by CYP450. Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EET metabolite, have been documented by GC/MS in pregnancy induced hypertension. (±)14(15)-EET methyl ester is a more stable form used for long-term storage. It can be readily hydrolyzed to the free acid as needed.
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