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A metabolite of EPA
Eicosapentaenoic acid is an ω-3 fatty acid abundantly available in marine organisms. (±)14(15)-DiHETE is one of the major metabolites produced when EPA is incubated with rat liver microsomes and a rat colitis homogenate. The route of production likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-6 double bond followed by conversion to the vicinal diols by epoxide hydrolase. (±)14(15)-DiHETE is excreted in significant quantities by humans ingesting fish oil supplements.
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