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安捷凯生物医药，安捷凯化学
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  2. Reactive oxygen species (ROS)
  3. CAY10564
  • CAY10564
CAY10564的可视化放大

CAY10564

A pH-controlled nitric oxide donor

原价
￥512-7187
价格
￥ 410-5750
CAY10564的二维码

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  • 库存: 现货
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  • 货号: ajcx18246
  • CAS: N/A
  • 别名: 4(<span class=\foreign\>p</span>chlorophenyl)1,3,2Oxathiazolylium5olate
  • 分子式: C8H6ClNO2S
  • 分子量: 215.7
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.25 mg/ml,Ethanol: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, at 37°C and relaxes phenylephrine-constricted rat aortic strips 59% and 16% at pH 6.0 and 7.4, respectively.

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