PAR3 (1-6) amide (mouse) (trifluoroacetate salt)

A peptide agonist of PAR1 and PAR2

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库存: 现货

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500ug

￥1750.00

1400.00

- +
1mg

￥3350.00

2680.00

- +

已选 0 种 0 瓶

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货号: ajcx18830
CAS: N/A
别名: H-Ser-Phe-Asn-Gly-Gly-Pro-NH2, SFNGGP amide, SFNGGP-NH2, SFN-NH2
分子式: C25H36N8O8?XCF3COOH
分子量: 576.6
纯度: >98%
溶解度: Water: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4. It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM. PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.