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  2. Reactive oxygen species (ROS)
  3. 13(S)-HODE-d4
  • 13(S)-HODE-d4
13(S)-HODE-d4的可视化放大

13(S)-HODE-d4

An internal standard for the quantification of 13-HODE

原价
￥2275-8125
价格
￥ 1820-6500
13(S)-HODE-d4的二维码

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  • 库存: 现货
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  • 货号: ajcx21088
  • CAS: 139408-39-2
  • 别名:
  • 分子式: C18H28D4O3
  • 分子量: 300.5
  • 纯度: >98%
  • 溶解度: DMF: >50 mg/ml (per Rao Maddipati),DMSO: >50 mg/ml (per Rao Maddipati),Ethanol: >50 mg/ml (per Rao Maddipati),PBS pH 7.2: >1 mg/ml (from 13(S)-HODE)
  • 储存: Store at -20°C
  • 库存: 现货

Background

13(S)-HODE-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of 13(S)-HODE by GC- or LC-mass spectrometry. 13(S)-HODE is produced by incubation of linoleic acid with plant and mammalian lipoxygenases. It has been shown to inhibit the adhesion of tumor cells to the endothelium at concentrations around 1 µM,1,2 and down regulates the expression of the IRGpIIb/IIIa receptor.3



1.Buchanan, M.R., Haas, T.A., Lagarde, M., et al.13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOXThe Journal of Biological Chemisty26016056-16059(1985) 2.Honn, K.V., Nelson, K.K., Renaud, C., et al.Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasisProstaglandins44(5)413-429(1992) 3.Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al.Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acidCancer Res.49(4)1029-1037(1989)

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