An internal standard for the quantification of mitoquinol
Mitoquinol-d15 is intended for use as an internal standard for the quantification of mitoquinol by GC- or LC-MS. Mitoquinol is a mitochondria-targeted antioxidant and reduced form of mitoquinone .1 It reduces hydrogen peroxide production in succinate-fueled isolated bovine aortic endothelial mitochondria.2
1.Kelso, G.F., Porteous, C.M., Coulter, C.V., et al.Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic propertiesJ. Biol. Chem.276(7)4588-4596(2001) 2.O’Malley, Y., Fink, B.D., Ross, N.C., et al.Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondriaJ. Biol. Chem.281(52)39766-39775(2006)
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