1-Ethyl-1-nitrosourea (hydrate)

A DNA alkylating agent

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库存: 现货

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1g

￥562.00

450.00

- +
5g

￥1950.00

1560.00

- +
10g

￥3625.00

2900.00

- +
25g

￥7575.00

6060.00

- +

已选 0 种 0 瓶

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货号: ajcx25890
CAS: N/A
别名: ENU, Ethylnitrosourea, N-Ethyl-N-nitrosourea, N-Nitroso-N-ethylurea
分子式: C3H7N3O2 ? XH2O
分子量: 117.1
纯度: >98%
溶解度: DMF: 15 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL,PBS (pH 7.2): 3 mg/mL
储存: -20°C
库存: 现货

Background

1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.¹ It increases the concentrations of O⁶-ethylguanine, N⁷-ethylguanine, N⁷-ethyladenine, and N³-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenic in vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.²

1.Goth, R., and Rajewsky, M.F.Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosoureaProc. Natl. Acad. Sci. USA71(3)639-643(1974) 2.Druckrey, H., Ivankovi?, S., and Preussmann, R.Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant ratsNature210(5043)1378-1379(1966)