Dopamine 4-O-Sulfate

An inactive metabolite of dopamine

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1mg

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Background

Dopamine 4-O-sulfate is an inactive metabolite of the catecholamine dopamine .^1,2 It is formed from dopamine by the sulfotransferase (SULT) isoform SULT1A3.³ Dopamine 4-O-sulfate is found at lower levels in the brain and circulation than dopamine 3-O-sulfate .^1,3

1.Suominen, T., Uutela, P., Ketola, R.A., et al.Determination of serotonin and dopamine metabolites in human brain microdialysis and cerebrospinal fluid samples by UPLC-MS/MS: Discovery of intact glucuronide and sulfate conjugatesPLoS One8(6)e68007(2013) 2.Kyncl, J.J., Buckner, S.A., Brondyk, H., et al.Adrenergic and dopaminergic properties of dopamine sulfoconjugatesJ. Cardiovasc. Pharmacol.7(6)1198-1204(1985) 3.It?aho, K., Alakurtti, S., Yli-Kauhaluoma, J., et al.Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulationBiochem. Pharmacol.74(3)504-510(2007)