A coumarin with diverse biological activities
Meranzin is a coumarin that has been found in Murraya exotica and has diverse biological activities.1,2 It is cytotoxic to NSCLC-N6 and KB cancer cells (IC50s = 14.6 and 12.3 ?g/ml, respectively).2 Meranzin (10 mg/kg) increases the latency to paw withdrawal in the hot plate test and reduces xylene-induced ear edema in mice.1 It decreases paw edema induced by carrageenan in rats when administered at the same dose.
1.Wu, L., Li, P., Wang, X., et al.Evaluation of anti-inflammatory and antinociceptive activities of Murraya exoticaPharm. Biol.48(12)1344-1353(2010) 2.Kofinas, C., Chinou, L., Loukis, A., et al.Cytotoxic coumarins from the aerial parts of Tordylium apulum and their effects on a non-small-cell bronchial carcinoma cell linePlanta Med.64(2)174-176(1998)
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