BAY 73-1449

BAY73-1449是一种选择性前列环素受体(prostacyclinreceptor,IP)的拮抗剂，在人HEL细胞和大鼠DRG的cAMP分析中具有很高的效价(IC50值小于0.1nM)。BAY73-1449可用于降血压的研究。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥3262.00

2610.00

- +
10mg

￥5400.00

4320.00

- +
25mg

￥10250.00

8200.00

- +
50mg

￥16562.00

13250.00

- +
100mg

￥25112.00

20090.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1].

BAY 73-1449 (0.1-1 mg/kg; i.v.) does not significantly reduce mesenteric inflow, but significantly reduces splenic shunt vessel outflow in rats[1].BAY 73-1449 (1-5 mg/kg, s.c. once daily for 7 d) has no effects on the degree of porto-systemic shunting in rats[1].BAY 73-1449 (1 mg/kg, s.c. once daily for 7 d), has no effects on portal pressures in rats[1]. Animal Model: Male Wistar rats (250-350 g) are ligated portal vein[1]

[1]. Bexis S, et, al. Vascular actions of the prostacyclin receptor antagonist BAY 73-1449 in the portal hypertensive rat. Eur J Pharmacol. 2008 Aug 20;590(1-3):322-6.