diABZI-C2-NH2

diABZI-C2-NH2是一种含有伯胺功能的活性类似物，是一种 STING 激动剂。

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库存: 现货

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5mg

￥8412.00

6730.00

- +
10mg

￥13350.00

10680.00

- +

已选 0 种 0 瓶

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Background

diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].

The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].

[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53]. Nature. 2018;564(7736):439-443.