E3 ligase Ligand-Linker Conjugates 12

E3 ligase Ligand-Linker Conjugates 12 是一种合成的 E3 ligase Ligand-Linker Conjugates ，它包含基于 (S,R,S)-AHPC 的 VHL 配体和 PROTAC 技术中使用的 3 单元 PEG 接头。

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库存: 现货

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数量
100mg

￥3375.00

2700.00

- +
500mg

￥12825.00

10260.00

- +
1g

￥23650.00

18920.00

- +
2g

￥33112.00

26490.00

- +

已选 0 种 0 瓶

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货号: ajce50242
CAS: 1797406-80-4
别名: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12
分子式: C30H43N7O7S
分子量: 645.77
纯度: >98%
溶解度: DMSO : 50 mg/mL (77.43 mM)
储存: Store at -20°C
库存: 现货

Background

E3 ligase Ligand-Linker Conjugates 12 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.

E3 ligase Ligand-Linker Conjugates 12 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].

[1]. WO/2016/146985A1 [2]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7.