(R)-Nedisertib

(R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体，对DNA-PK的IC50值为7-30nM。

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Background

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1]. DNA-PK|7-30 nM (IC50)

Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].

[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

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