A taxane diterpenoid with α-glucosidase inhibitory and anticancer activities
7-epi-10-Deacetyltaxol is a taxane diterpenoid and derivative of paclitaxel that has been found in Taxus and has α-glucosidase inhibitory and anticancer activities.1,2 It inhibits α-glucosidase (IC50 = 48.8 ?M) and is cytotoxic to HeLa cells (IC50 = 0.085 nM).1 7-epi-10-Deacetyltaxol induces apoptosis and DNA fragmentation in HepG2 hepatocellular carcinoma cells in a concentration-dependent manner.2
1.Dang, P.H., Nguyen, H.X., Duong, T.T.T., et al.α-glucosidase inhibitory and cytotoxic taxane diterpenoids from the stem bark of Taxus wallichianaJ. Nat. Prod.80(4)1087-1095(2017) 2.Subban, K., Singh, S., Subramani, R., et al.Fungal 7-epi-10-deacetyltaxol produced by an endophytic Pestalotiopsis microspora induces apoptosis in human hepatocellular carcinoma cell line (HepG2)BMC Complement. Altern. Med.17(1)504(2017)
动态评分
0.0