Skp2 Inhibitor C1

An inhibitor of Skp2-mediated p27 degradation

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10mg

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1220.00

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50mg

￥6337.00

5070.00

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100mg

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200mg

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Background

SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation.¹ It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 μM. SKPin C1 increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells.²

1.Wu, L., Grigoryan, A.V., Li, Y., et al.Specific small molecule inhibitors of Skp2-mediated p27 degradationChem. Biol.19(12)1515-1524(2012) 2.Pavlides, S.C., Huang, K.-T., Reid, D.A., et al.Inhibitors of SCF-Skp2/Cks1 E3 ligase block estrogen-induced growth stimulation and degradation of nuclear p27kip1: Therapeutic potential for endometrial cancerEndocrinology154(11)4030-4045(2013)