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  • Veratramine
Veratramine的可视化放大

Veratramine

An inhibitor of hedgehog signaling

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Veratramine的二维码
  • 库存: 现货
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  • 5mg
    ¥550.00
    440.00
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  • 10mg
    ¥875.00
    700.00
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  • 50mg
    ¥3487.00
    2790.00
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  • 100mg
    ¥5500.00
    4400.00
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  • 200mg
    ¥0.00
    0.00
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  • 500mg
    ¥0.00
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  • 货号: ajce60032
  • CAS: 60-70-8
  • 别名: 黎芦碱; NSC17821; NSC23880
  • 分子式: C27H39NO2
  • 分子量: 409.6
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 100 mg/mL (244.14 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine , plays a key role in morphogenesis and has potential applications in the treatment of cancer.1,2,3 Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.4 Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.5,6


1.Heretsch, P., Tzagkaroulaki, L., and Giannis, A.Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectivesAgnew. Chem. Int. Ed. Engl.49(20)3418-3427(2010) 2.Xu, F.G., Ma, Q.Y., and Wang, Z.Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancerCancer Lett.283(2)119-124(2009) 3.Mahindroo, N., Punchihewa, C., and Fujii, N.Hedgehog-Gli signaling pathway inhibitors as anticancer agentsJ. Med. Chem.52(13)3829-3845(2009) 4.Tang, J., Li, H.L., Shen, Y.H., et al.Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricumPhytother. Res.24(6)821-826(2010) 5.Nagata, R., Izumi, K., Iwata, S.i., et al.Mechanisms of veratramine-induced 5-HT syndrome in miceJpn. J. Pharmacol.55139-146(1991) 6.Fukuma, K.Actions of veratramine on the central nervous systemJpn. J. Pharmacol.5102-114(1956)

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