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Urotensin II (human)

A neuropeptide agonist of the urotensin II receptor

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  • 1mg
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  • 货号: ajcf10308
  • CAS: 251293-28-4
  • 别名:
  • 分子式: C64H85N13O18S2
  • 分子量: 1388.57
  • 纯度: >98%
  • 溶解度: Soluble in 20% acetonitrile / sterile Water
  • 储存: Desiccate at -20°C
  • 库存: 现货

Background

Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

参考文献:
[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.

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