SIRT2-IN-9 (compound 12) 是 SRIT2 的选择性抑制剂,IC50 值为 1.3 μM。SIRT2-IN-9 抑制 MCF-7 乳腺癌细胞的增殖活性。SIRT2-IN-9 可用于癌症的研究。
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SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer[1].
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s >300 μM[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
Cell Proliferation Assay[1]
Cell Line: | MCF-7 breast cancer cell line |
Concentration: | 0-50 μM |
Incubation Time: | 72 hours |
Result: | Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells. |
Western Blot Analysis[1]
Cell Line: | MCF-7 breast cancer cell line |
Concentration: | 6.25, 12.5, 25 and 50 μM |
Incubation Time: | 6 hours |
Result: | Dose-dependently increased acetylation of α-tubulin protein. |
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