NH-bis-PEG2

NH-bis-PEG2 是一种不可裂解 (non-cleavable) 的 2 单元 PEG 的 ADC linker，用于抗体药物偶联物 (ADCs) 的合成。NH-bis-PEG2 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

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库存: 现货

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数量
250mg

￥2950.00

2360.00

- +
500mg

￥4662.00

3730.00

- +
1g

￥7200.00

5760.00

- +

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Background

NH-bis-PEG2 is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH-bis-PEG2 is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Brown A, et al. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750.