ACG416B (compound 18) 是一种有效的胆碱激酶 (ChoK) 抑制剂,IC50 值为 0.4 μM。ACG416B 对 HT-29 人结肠癌细胞具有更高的 ChoK 抑制和抗增殖活性。
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ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC50 of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell[1].
[1]. onejo-García A, et al. Influence of the linker in bispyridium compounds on the inhibition of human choline kinase. J Med Chem. 2004 Oct 21;47(22):5433-40.
DMNPE-caged ATP diammonium salt
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