BRD0209

BRD0209 是一种有效、选择性和双重的 GSK3α/β 抑制剂 (GSK3α IC50 = 19 nM; GSK3β IC50 = 5 nM)。BRD0209 还是一种可逆的 ATP 竞争性抑制剂，具有快关动力学 (Ki 分别为 4.2 nM)。BRD0209 是一种三环吡唑并四氢喹啉酮化合物。BRD0209 具有研究心境障碍疾病的潜力。

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库存: 现货

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包装

价格

促销价

数量
10mg

￥4850.00

3880.00

- +
25mg

￥9175.00

7340.00

- +
50mg

￥12825.00

10260.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcf19310
CAS: 1597439-87-6
别名:
分子式: C22H25N3O
分子量: 347.45
纯度: >98%
溶解度: DMSO : 62.5 mg/mL (179.88 mM; Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

BRD0209 is a potent, selective and dual inhibitor of GSK3α/β inhibitor (GSK3α IC₅₀ = 19 nM; GSK3β IC₅₀ = 5 nM). BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (K_i = 4.2 nM, respectively). BRD0209 is a tricyclic pyrazolotetradroquinolinone compound. BRD0209 has the potential for the research of mood disorder diseases^[1].

[1]. Wagner FF, et al. Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 2016;11(7):1952-1963.