TASK-1-IN-1

TASK-1-IN-1 是一种有效的选择性的 TASK-1 (Potassium Channel) 抑制剂，IC50 为 148 nM。TASK-1-IN-1 对 TASK-3 通道 (IC50 为 1750 nM) 的抑制作用降低，并且对其他 K+ 通道没有显着影响。TASK-1-IN-1 具有抗癌作用。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
10mg

￥1737.00

1390.00

- +
25mg

￥3775.00

3020.00

- +
50mg

￥5937.00

4750.00

- +
100mg

￥9175.00

7340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

IC50: 148 nM (TASK-1) and 1750 nM (TASK-3)^[1]

TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.

TASK-1-IN-1 (compound F3) blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells, indicating that it is acting in TASK-1 channels^[1].

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 cells
Concentration:	10 μM
Incubation Time:	96 hours
Result:	Showed an antiproliferative activity of ～45% on the cell line MCF-7.

[1]. Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027.