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Temporin A

Temporin A 是从 Rana temporaria 皮肤中分离得到的一种短α螺旋抗菌肽。Temporin A 对广谱革兰氏阳性菌有效。Temporin A 直接与微生物的细胞膜相互作用,在抗菌浓度下对红细胞无毒。Temporin A 还具有抗真菌活性,可对抗酵母样白色念珠菌。

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Temporin A的二维码
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  • 5mg
    ¥2062.00
    1650.00
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  • 10mg
    ¥3312.00
    2650.00
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  • 货号: ajcf21668
  • CAS: 188713-69-1
  • 别名:
  • 分子式: C68H117N17O14
  • 分子量: 1396.76
  • 纯度: >98%
  • 溶解度:
  • 储存: Store at -20°C
  • 库存: 现货

Background

Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans)[1][1][3].

Temporin A (TA) is a small, basic, highly drophobic, antimicrobial peptide amide (FLPLIGRVLSGIL-NH2) found in the skin of the European red frog, Rana temporaria. It has variable antibiotic activities against a broad spectrum of microorganisms, including clinically important Methicillin-sensitive and -resistant Staplococcus aureus as well as Vancomycin-resistant Enterococcus faecium strains[2].

[1]. M?ntyl? T, Sirola H, Kansanen E, et al. Effect of temporin A modifications on its cytotoxicity and antimicrobial activity. APMIS. 2005;113(7-8):497-505.
[2]. Wade D, et al. Antibacterial activities of temporin A analogs. FEBS Lett. 2000;479(1-2):6-9.
[3]. Kamysz W, et al. Temporin A and its retro-analogues: synthesis, conformational analysis and antimicrobial activities. J Pept Sci. 2006;12(8):533-537.

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