TH-Z145

TH-Z145，一种亲脂性双膦酸盐，是一种 FPPS 抑制剂 (IC50: 210 nM)。

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Background

TH-Z145, a lipophilic bisphosphonate, is a FPPS inhibitor (IC₅₀: 210 nM)^[1].

TH-Z145 (20 μg, i.p.) exhibits strong proplactic effects in a pathogenic influenza model^[1].

Animal Model:	B16-OVA cells (s.c.) xenograft mice model^[1].
Dosage:	20 μg
Administration:	Intraperitoneal injection (i.p.)
Result:	Inhibited tumor growth and prolonged survival.

[1]. Xia Y, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. 2018 Nov 1;175(4):1059-1073.e21.

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