安捷凯在线客服
- 客服:
- 电话: 13061953619
- 微信:
TNG260 是一种CoREST 选择性脱乙酰酶 (CoreDAC) 抑制剂。 TNG260 抑制 HDAC1 的选择性是 HDAC3 的 10 倍。 TNG260 导致 HDAC1 抑制,逆转由 STK11 缺失驱动的抗 PD1 耐药性。 TNG260 减少嗜中性粒细胞的瘤内浸润。 TNG260 表现出免疫介导的细胞杀伤。
TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing[1].
[1]. Ahronian L, et al. TNG260, a CoREST-selective deacetylase inhibitor, reverses anti-PD1 resistance driven by loss of STK11[J]. J Immunother, 2022, 10(2): A1-A1595.
动态评分
0.0