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Topoisomerase I inhibitor 8 是一种强效 topoisomerase I 抑制剂。Topoisomerase I inhibitor 8 是一种喜树碱六环类似物,对肿瘤细胞有毒性。
SN-38 , with IC50 of compound/IC50 of SN-38=0.51[1].
[1]. Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18.
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