2',3'-Dideoxyadenosine-5'-O-triphosphate (sodium salt)

一种反转录酶抑制剂，是ddA和ddI的活性代谢产物。

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2.4mg

￥3475.00

2780.00

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货号: ajcf22908
CAS: 99827-72-2
别名: ddATP, Dideoxyadenosine-5'-triphosphate
分子式: C10H12N5O11P3 ? 4Na
分子量: 563.1
纯度: >98%
溶解度: Water: Soluble
储存: Store at -80°C
库存: 现货

Background

2',3'-Dideoxyadenosine-5'-O-triphosphate is a reverse transcriptase inhibitor (K_is = 20 and 37 nM for the HIV and visna virus enzymes, respectively) and an active metabolite of 2′,3′-dideoxyadenosine and didanosine .^1,2,3 It is formed from ddI via a 2',3'-dideoxyAMP intermediate by phosphoribosyl pyrophosphate synthase (PRS).³ It inhibits DNA polymerase isolated from mouse Ehrlich ascites tumor cells in the presence of ATP or GDP (K_is = 60 and 18 μM, respectively).⁴ 2',3'-Dideoxyadenosine-5'-O-triphosphate and other dideoxynucleoside 5'-triphosphates are commonly used to terminate chain extension by Taq polymerases in PCR assays.⁵