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  • EP4 Antagonist 14
EP4 Antagonist 14的可视化放大

EP4 Antagonist 14

一种EP4拮抗剂

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EP4 Antagonist 14的二维码
  • 库存: 现货
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  • 1mg
    ¥1137.00
    910.00
    - +
  • 5mg
    ¥4775.00
    3820.00
    - +
  • 10mg
    ¥8987.00
    7190.00
    - +
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  • 货号: ajcf22950
  • CAS:
  • 别名: PGE2 Receptor 4 Antagonist 14, Prostaglandin E2 Receptor 4 Antagonist 14
  • 分子式: C24H18F3N3O3
  • 分子量: 453.4
  • 纯度: >98%
  • 溶解度: DMF: 20 mg/ml,DMSO: 20 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

EP4 antagonist 14 is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM in a reporter assay using HEK293 cells expressing the human receptor.1 It inhibits PGE2-induced β-arrestin recruitment in the same cells (IC50 = 0.9 nM). EP4 antagonist 14 (10 μM) decreases PGE2-induced expression of mRNA encoding Il-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. In vivo, EP4 antagonist 14 (30 mg/kg per day), in combination with an anti-PD-1 antibody, inhibits tumor growth and increases infiltration of CD8+ T cells into tumors in a CT26 murine colon cancer model.

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