8-Chloroadenosine-5'-triphosphate (sodium salt)

8-氯cAMP的活性代谢物。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
2.7mg

￥4300.00

3440.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

8-Chloroadenosine-5’-triphosphate (8-chloro ATP) is an active metabolite of the anticancer agent 8-chloro cAMP and a derivative of the nucleotide adenosine 5’-triphosphate .¹ It is formed from 8-chloro cAMP via 8-chloroadenosine and mono- and diphosphate intermediates. 8-chloro ATP accumulates for up to 12 hours following application of 8-chloro cAMP or 8-chloroadenosine and is associated with inhibition of cell growth, decreases in endogenous ATP levels, and a reduction in RNA, but not DNA, synthesis in patient-derived multiple myeloma cells. It inhibits topoisomerase II-α-dependent relaxation of supercoiled pUC19 DNA when used at concentrations of 1.5 to 8 mM, as well as reduces topoisomerase II-α-catalyzed ATP drolysis by 50% at 1 mM, in K562 human myelocytic leukemia cells.²