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Sorafenib (D4)
Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂,抑制 Raf-1,B-Raf 和 VEGFR-3 的 IC50 分别为6 nM,20 nM,22 nM。
Sorafenib (D3)
An internal standard for the quantification of sorafenib
RAF mutant-IN-1
RAF mutant-IN-1 是RAF kinase 的抑制剂,信息来自专利WO2019107987A1,对C-RAF 340D/Y341D、B-RAFV600E 和B-RAFWT 的IC50 值分别为 21 nM、30 nM和392 nM。
Isomerazin
A coumarin with antioxidant and anti-inflammatory activities
HG6-64-1
HG6-64-1是有效选择性的B-Raf抑制剂, 来自专利专利WO 2011090738 A2,化合物实例9 (XI-1)。在B-raf V600E转化的Ba/F3细胞中IC50值为0.09 μM。
Draflazine
Draflazine (R-75231) 是一种 ENT1 抑制剂。Draflazine (R-75231) 在 CFA 机械痛觉过敏模型,热力学和机械痛觉过敏的卡拉胶炎症模型中完全逆转了超敏反应。
Anthraflavic acid
2,6-Dihydroxyanthraquinone (Anthraflavic acid, Anthraflavin) is a potent and specific inhibitor of cytochrome P-448 activity.
C25-140
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inf
Furafylline
Furafylline, as a long-acting replacement for theophylline in the treatment of asthma, is a methylxanthine derivative[1].
AD80
AD80, a multikinase inhibitor, shows strong activity against human RET (c-RET), BRAF, S6K, and SRC but were much less active than either AD57 or AD58 against mTOR. The IC50 value for RET is 4 nM.
PLX8394
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
Rafigrelide (3,3-Dimethylanagrelide)
Rafigrelide (3,3-Dimethylanagrelide) 是一种血小板降低剂,也具有抗血栓形成的特性。
Stachyose tetrahydrate
Stachyose is a natural sugar found in many foods like beans and vegetables.
Sorafenib N-oxide
An active metabolite of sorafenib
Nalfurafine
An Analytical Reference Standard