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CFTR corrector 6
CFTR corrector 6 是有效的囊性纤维化跨膜电导调节剂 (CFTR) 增强剂。CFTR corrector 6 有潜力用于囊性纤维化 (CF) 和其他 CFTR 相关疾病的研究。
RNF5 inhibitor inh-02
RNF5 inhibitor inh-02 是 E3 泛素连接酶 RNF5/RMA1 的有效抑制剂。RNF5 inhibitor inh-02 导致 F508del 突变纯合子支气管上皮细胞 F508del-CFT 显著挽救 (EC50=2.2 uM)。RNF5 inhibitor inh-02 可用于囊性纤维化研究。
Icenticaftor
Icenticaftor (QBW251, NVP-QBW251) is an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel with EC50 of 79 nM and 497 nM for F508del CFTR and G551D CFTR in Fisher Rat Thyroid (FRT) cells.
Navocaftor
Navocaftor 作为一种囊性纤维化跨膜调节剂 (CFTR),是一种蛋白调节剂 (US 20200377491 Al,例 1)。
PG 01
PG 01 是一种有效的 CFTR Cl-通道增效剂。
Ivacaftor (VX-770)
A CFTR potentiator
IOWH-032
A modulator of CFTR
PTC124(Ataluren)
Selective inducer of stop codon read-through
Ivacaftor benzenesulfonate
Ivacaftor hydrate
CFTRinh-172
A potent CFTR channel blocker
VX-661
An investigational compound that promotes the maturation of delta F508 CFTR
VX-809
A F508del-CFTR corrector
PPQ-102
A CFTR channel inhibitor
GlyH-101
A reversible CFTR channel blocker