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Retaspimycin
Retaspimycin 是一种有效的 Hsp90 抑制剂,对 Hsp90 和 Grp9 的 EC50 均为 119 nM。
Hsp70-derived octapeptide
Hsp70-derived octapeptide 是热休克蛋白70 (Hsp70) C 末端保守的八肽,可与 TPR 域相互作用。
p5 Ligand for Dnak and DnaJ
p5 Ligand for Dnak and DnaJ 是一种九肽,对应于线粒体天冬氨酸氨基转移酶前序列的 23 个残基部分的主要结合位点。p5 Ligand for Dnak and DnaJ 是 DnaK (E. coli Hsp70) 和 DnaJ (E. coli Hsp40) 的高亲和力配体。
HSP27 inhibitor J2
HSP27 inhibitor J2 (J2) is an inhibitor of HSP27, which significantly induces abnormal HSP27 dimer formation and inhibits HSP27 macropolymer production[1-3].
ATI-2341 TFA
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.
4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline
A heterocyclic building block
EN219
An RNF114 recruiter
CCT018159
An Hsp90 inhibitor
NSC 12
An FGF inhibitor
TAS-116
Arimoclomol maleate (BRX-220)
A co-inducer of heat shock proteins
AUY922 (NVP-AUY922)
BIIB021
A potent, orally-available Hsp90 inhibitor
ML-346
An activator of the heat shock response
HM03
HM03 是一种有效的选择性的热休克 70 kDa 蛋白 5, HSPA5 (也称为 Bip,Grp78) 抑制剂,具有抗肿瘤活性。