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PAC
PAC是由抗体通过linker与PROTAC偶联而组成的。PAC的详细信息请参考专利文献WO2017201449A1中的化合物PAC1。与PROTAC(无Ab)相比,PAC更加显著降低雌激素受体-α(ERα)水平。
PROTAC BRD9 Degrader-1
PROTACBRD9Degrader-1是一种先导PROTACBRD9化学降解剂,可用作研究BAF复合物的选择性探针。
VH 032, amine
Derivative of the von Hippel-Lindau (VHL) ligand, VH 032; commonly used as a precursor to a PROTAC? that hijacks VHL as the E3 ubiquitin ligase component
A 410099.1 amide-PEG3-amine
A 410099.1 amide-PEG4-amine
Functionalized IAP ligand for PROTAC? research and development; incorporates an IAP ligand plus an amide-PEG4 linker with terminal amine ready for conjugation to a target protein ligand
A 410099.1 amide-PEG5-amine
Functionalized IAP ligand for PROTAC? research and development; incorporates an IAP ligand plus an amide-PEG5 linker with terminal amine ready for conjugation to a target protein ligand
A 410099.1 amide-PEG2-amine
A 410099.1 amide-alkylC4-amine
VH 032, phenol
VH 032,苯酚是基于 VH032 的 VHL 配体。 VH 032,苯酚可以通过接头连接到蛋白质的配体上,形成PROTAC。
VH 101 phenol-alkylC4-amine
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal amine ready for conjugation to a target protein ligand
VH 101 phenol-alkylC6-amine
Functionalized von-Hippel-Lindau protein ligand (VHL) for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand
VH 101, phenol
VH 101,苯酚是基于 VH032 的 VHL 配体。 VH 101,苯酚可以通过接头连接到蛋白质的配体(例如,SMARCA BD 配体)以形成 PROTAC(例如,PROTAC 1)。 PROTAC 1 是 SMARCA2 和 SMARCA4 的部分降解剂。
Homo-PROTAC cereblon degrader 1
Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3.
PROTAC BET-binding moiety 1
PROTACBET-bindingmoiety1是合成高亲和力BET抑制剂的一个关键中间体。
PROTAC ER Degrader-3
PROTACERDegrader-3是合成PAC的中间体。PAC是由抗体通过linker与PROTAC偶联而组成的。PAC的详细信息请参考专利文献WO2017201449A1中的化合物LP2。与PROTAC(无Ab)相比,PAC更加显著降低雌激素受体-α(ERα)水平。