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GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂,IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2,IC50 值分别为 3.0 μM 和 1.4 μM。
Jervine
An inhibitor of the hedgehog signaling pathway
SANT-2
A Smoothened receptor antagonist
CUR 61414
A potent inhibitor of hedgehog-induced activity
AY 9944 dihydrochloride
A cholesterol synthesis inhibitor
Cyclopamine
An inhibitor of hedgehog signaling
MK-4101
20(S)-Hydroxycholesterol
An allosteric Smo agonist
LY2940680
A Smo antagonist
Oxy-16
A synthetic oxysterol
Robotnikinin
A direct inhibitor of sonic hedgehog
PF-05274857 (hydrochloride)
PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-05274857(盐酸盐)具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
Cyclopamine-KAAD
A potent inhibitor of hedgehog signaling
Hedgehog Antagonist VIII
An inhibitor of hedgehog pathway signaling
N-Palmitoyl-L-Aspartate
A natural N-acylaspartate