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AEG 3482
An inhibitor of p75NTR- and NRAGE-induced apoptosis
Cinchonine ((8R,9S)-Cinchonine)
Cinchonine (LA40221) is an alkaloid and a stereoisomer and pseudo-enantiomer of cinchonidine.
[8]-Shogaol
[8]-Shogaol,生姜中的一种刺激性酚类化合物,具有抗血小板活性 (IC50=5 μM) 和抑制 COX-2 (IC50=17.5 μM)。[8]-Shogaol 诱导人白血病细胞凋亡。
Elesclomol (STA-4783)
An apoptosis inducer
Carvacrol
A monoterpene with diverse biological activities
Psoralidin
A furanocoumarin with anti-cancer activity
D-myo-Inositol-1,5,6-triphosphate (sodium salt)
Inositol phosphate intermediate
ASK1-IN-1
ASK1-IN-1 是一种有效的、口服的、选择性的 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 2.87 nM。
Tosyl Phenylalanyl Chloromethyl Ketone
An inhibitor of chymotrypsin-like serine proteases
CAY10512
A potent inhibitor of NF-κB
(E)-Flavokawain A
A chalcone with diverse biological activities
Forodesine (BCX-1777 freebase)
A nucleoside analog and PNP inhibitor
MPT0B392
MPT0B392 是一种口服活性的喹啉衍生物,作用于 c-Jun N末端激酶 (JNK) 和 apoptosis 的激活剂。MPT0B392 抑制微管蛋白聚合,通过激活 JNK 诱导细胞有丝分裂停滞,线粒体膜电位丧失和 caspases 裂解,最终导致细胞凋亡。MPT0B392 是一种新型微管解聚剂,可增强西罗莫司对耐药急性白血病细胞和多药耐药细胞系的细胞毒性。
1,2-Dipalmitoyl-sn-glycero-3-PS (sodium salt)
A phospholipid and marker for apoptosis
BTR-1
BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. BTR-1 affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.