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SAG hydrochloride
Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
Betahistine
A histamine H3 receptor antagonist and histamine H1 receptor agonist
PF-05274857 (hydrochloride)
PF-05274857 (hydrochloride) 是一种有效的、选择性的、具有口服活性的脑渗透性 Smo 拮抗剂,IC50 为 5.8 nM,Ki 为 4.6 nM。 PF-05274857(盐酸盐)具有研究肿瘤类型的潜力,包括由激活的 Hh 通路驱动的脑肿瘤和脑转移。
GDC-0449 (Vismodegib)
GDC-0449 (Vismodegib) (GDC-0449) 是一种具有口服活性的hedgehog 通路抑制剂,IC50 为3 nM。 GDC-0449 (Vismodegib) 还抑制 P-gp、ABCG2,IC50 值分别为 3.0 μM 和 1.4 μM。
Cyclopamine
An inhibitor of hedgehog signaling
Betahistine mesylate
Betahistine mesylate is the mesylate salt form of Betahistine, a histamine analog and H3 receptor agonist that serves as a vasodilator.
JFD01307SC
JFD01307SC ([(1,1-dioxidotetrahydrothien-3-yl)amino]acetic acid) shows activity against M.tuberculosis with minimum inhibitory concentrations (MICs) in the range of 8 to 16 ?g/ml. JFD01307SC may targets enzymes involved in glutamine biosynthesis.
MK-4101
A Smoothened receptor antagonist
N-Palmitoyl-L-Aspartate
A natural N-acylaspartate
SJ6986
A degrader of GSPT1 and GSPT2
2-Amino-6-chloropurine
A precursor in the synthesis of nucleoside analogs
20(S)-Hydroxycholesterol
An allosteric Smo agonist
Jervine
An inhibitor of the hedgehog signaling pathway
RU-SKI 43
An inhibitor of hedgehog acyltransferase
Purmorphamine
Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。