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ZYZ-488
ZYZ-488 是一种竞争性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制剂,抑制结合蛋白 procaspase-9 和 procaspase-3 的激活。
Tomatine
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
Thevetiaflavone
Thevetiaflavone 可以上调 Bcl?2 的表达,下调 Bax 和 caspase-3 的表达。
Phenoxodiol
A phenol with anticancer activity
Gardenin B
Gardenin B 是从 Baccharis scandens 中分离出的一种黄酮类化合物。Gardenin B 能诱导人白血病细胞死亡,诱导的凋亡发生与多个 caspases 相关。
Eupatorin
A flavonoid with diverse biological activities
Emricasan
A pan-caspase inhibitor
Arnicolide D
A sesquiterpene lactone with anticancer activity
Tauroursodeoxycholate dihydrate
Tauroursodeoxycholatedihydrate(TUDCAdihydrate;UR906dihydrate;Taurolitedihydrate)是一种内质网应激抑制剂。Tauroursodeoxycholate显著降低凋亡分子如caspase-3和caspase-12表达。Tauroursodeoxycholate也抑制ERK。
Tauroursodeoxycholate (TUDCA)
A taurine-conjugated form of ursodeoxycholic acid
Ginsenoside Rh4
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
Ac-DEVD-CHO
Ac-DEVD-CHO (Caspase-3 Inhibitor I, N-Ac-Asp-Glu-Val-Asp-CHO) is a potent aldehyde inhibitor of Group II caspases with Ki values of 0.2 nM and 0.3 nM for for caspase-3 and caspase-7, respectively. Weak inhibition for caspase-2.
Clofilium tosylate
Clofiliumtosylate是一种钾通道(potassiumchannel)阻滞剂,作用于人早幼粒细胞白血病(HL-60)细胞,激活caspase-3而诱导凋亡。具有抗心律失常作用。
Chelidonic acid
A pyran with diverse biological activities
EP1013 (F1013)
EP1013 (F1013) (F1013) 是一种广谱 caspase 选择性抑制剂,用于 1 型糖尿病的研究。