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ML-211
A dual inhibitor of lysophospholipase 1 and 2
Cy3 alkyne (non-sulfonated)
used for Click chemistry to label any molecule bearing azide group.
GNE-617 hydrochloride
A potent Nampt inhibitor
AD57 (hydrochloride)
A polypharmacological cancer therapeutic
Daratumumab
Daratumumab (DARA) is a human IgG1 mAb targeting CD38, a 46-kDa type II transmembrane glycoprotein that is expressed at high levels on malignant cells in multiple myeloma (MM) [1,2].
GNE-781
GNE-781 (compound 19) is an orally active, highly potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP) with IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50 o
Rpn11-IN-1
Rpn11-IN-1是一种有效的选择性蛋白酶体亚基Rpn11抑制剂,IC50为390nM。
Belvarafenib
An inhibitor of B-RAF and C-RAF
CF53
CF53是一种高效、选择性、可口服的BET抑制剂,对BRD4BD1的Ki值为<1nM,Kd值为2.2nM,IC50值为2nM;CF53对BRD2,BRD3,BRD4和BRDTBET蛋白的BD1和BD2两个结构域都有高亲和性,对其选择性远高于非含溴结构域BET蛋白。CF53在体外和体内都具有显著的抗肿瘤活性[1]</su
RMC-4550
A SHP-2 inhibitor
FT-1518
FT-1518是一种选择性的,可口服的,有效的新一代mTORC1和mTORC2抑制剂,具有抗肿瘤的活性。
BCR-ABL-IN-2
BCR-ABL-IN-2是BCR-ABL1激酶的抑制剂,其对ABL1native和ABL1T315I的IC50值分别为57nM,773nM。
Elacestrant S enantiomer (RAD1901 S enantiomer)
ElacestrantSenantiomer是elacestrant的低活性对映体。Elacestrant(RAD1901)是有选择性和口服活性的雌激素受体(ER)的降解剂,对ERα和ERβ的IC50值分别为48和870nM。
Belvarafenib TFA
FLT3-IN-6
FLT3-IN-6 是一种有效、选择性的 FLT3-ITD (FLT3 突变体) 抑制剂,IC50 值为 1.336 nM。